Lectins in Human Cancer: Both a Devil and an Angel?
Publication in refereed journal

Times Cited
Web of Science5WOS source URL (as at 05/08/2020) Click here for the latest count
Altmetrics Information

Other information
AbstractLectins are a group of proteins which could recognize different sugar structures and specifically initiate reversible binding with them. Lectins are universally expressed in different organisms and undertake important biological roles. Understanding of their inherent roles and mechanisms that they employ has inspired researches with new ideas and applications. For example, along with the revelation of their anti-insect function, plant lectins exhibit great potential in agriculture. In human beings, lectins shoulder great missions in cell communication, differentiation and vesicle trafficking etc., aberrant expression of lectins is always associated with diseases. Mannan-binding lectin deficiency leads to immune disorder and liver sinusoidal endothelial cell lectin is involved in colorectal carcinoma liver metastasis. In this review, we present two contradictory roles of lectins in human cancer: the promotive roles of homologous lectins and suppressive roles of heterologous lectins in cancer development. Hopefully, this review will facilitate a better understanding of tumorigenesis and provide references for cancer treatment.
All Author(s) ListDan XL, Ng TB
Journal nameCurrent Protein and Peptide Science
Volume Number14
Issue Number6
PublisherBentham Science Publishers
Pages481 - 491
LanguagesEnglish-United Kingdom
Keywordsanti-cancer; cancer; galectin; Lectin
Web of Science Subject CategoriesBiochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY

Last updated on 2020-06-08 at 03:56