Impact of neonatal hepatitis B vaccination programme on age-specific prevalence of hepatitis B infection in teenage mothers in Hong Kong
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摘要We examined the impact of the neonatal hepatitis B immunization programme, first provided to all neonates born to mothers screened positive for hepatitis B surface antigen (HBsAg) in late 1983, on the age-specific prevalence of HBsAg carriage in teenage mothers managed in 1998-2008. HBsAg carriage was found in 2.5%, 2.7%, 8.8% and 8.0% of mothers aged <= 16, 17, 18, and 19 years, respectively (P=0.004), which was also correlated with advancing age (P=0.011). While neither difference nor correlation with age was found in mothers born before 1984, the prevalence of 1.2%, 1.5%, 7.1% and 8.3%, respectively, was significantly different among (P=0.008) and correlated with (P=0.002) age in mothers born 1984 onwards. Regression analysis indicated there was a significantly higher incidence of HBsAg carriage from age 17 onwards (adjusted odds ratio 2.55, 95% confidence interval 1.07-6.10, P=0.035), suggesting that the protective effect of the vaccine declined in late adolescence.
著者Lao TT, Sahota DS, Suen SSH, Chan PKS, Leung TY
期刊名稱Epidemiology and Infection
出版年份2013
月份10
日期1
卷號141
期次10
出版社CAMBRIDGE UNIV PRESS
頁次2131 - 2139
國際標準期刊號0950-2688
電子國際標準期刊號1469-4409
語言英式英語
關鍵詞Hepatitis B; neonatal immunization; pregnancy; teenage
Web of Science 學科類別Infectious Diseases; INFECTIOUS DISEASES; Public, Environmental & Occupational Health; PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH, SCI

上次更新時間 2020-29-10 於 00:19