A protocol for a multicentre randomised controlled trial of continuous beta-lactam infusion compared with intermittent beta-lactam dosing in critically ill patients with severe sepsis: the BLING II study
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AbstractBackground and rationale: Beta-lactam antibiotics are largely administered by bolus dosing, despite displaying time-dependent pharmacokinetics and pharmacodynamics and there being a strong rationale for continuous administration. The randomised controlled trials conducted to date comparing the mode of beta-lactam administration have been inconclusive and limited by non-equivalent dosing, unblinded administration and small sample sizes.
All Author(s) ListDulhunty JM, Roberts JA, Davis JS, Webb SAR, Bellomo R, Gomersall C, Shirwadkar C, Eastwood GM, Myburgh J, Paterson DL, Starr T, Udy AA, Paul SK, Lipman J
Journal nameCritical Care and Resuscitation
Volume Number15
Issue Number3
PublisherCollege of Intensive Care Medicine of Australia and New Zealand
Pages179 - 185
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesCritical Care Medicine; CRITICAL CARE MEDICINE; General & Internal Medicine

Last updated on 2021-15-09 at 00:42