Magnesium Sulphate for Aneurysmal Subarachnoid Hemorrhage: Why, How, and Current Controversy
Refereed conference paper presented and published in conference proceedings


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AbstractThe neuroprotective effect of magnesium sulphate infusion has been confirmed in experimental models. Pilot clinical trials using magnesium sulphate in patients with acute aneurysmal subarachnoid hemorrhage (SAH) have reported a trend toward a reduction in clinical deterioration due to delayed cerebral ischemia (DCI) and an improvement in clinical outcomes. However, our recent multicenter trials and systemic review failed to confirm benefit in neurological outcome. In post hoc analysis, data also did not support that a higher dose of magnesium sulphate infusion might improve clinical outcome. We here review the current literature, highlight these discrepancies, and explore alternatives.
All Author(s) ListWong GKC, Poon WS
Name of Conference11th International Conference on Cerebral Vasospasm: Neurovascular Events after Subarachnoid Hemorrhage
Start Date of Conference21/07/2011
End Date of Conference23/07/2011
Place of ConferenceCincinnati
Country/Region of ConferenceUnited States of America
Journal nameActa Neurochirurgica -Supplementum then Supplement- Wien-
Year2013
Month1
Day1
Volume Number115
PublisherSPRINGER-VERLAG WIEN
Pages45 - 48
ISBN978-3-7091-1191-8
ISSN0065-1419
LanguagesEnglish-United Kingdom
KeywordsClinical outcome; Delayed cerebral ischemia; Magnesium; Stroke; Subarachnoid hemorrhage
Web of Science Subject CategoriesClinical Neurology; Neurosciences & Neurology

Last updated on 2020-20-11 at 00:56