A pilot randomized study to assess immunogenicity, reactogenicity, safety and tolerability of two human papillomavirus vaccines administered intramuscularly and intradermally to females aged 18-26 years
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AbstractIntradermal administration of human papillomavirus (HPV) vaccines could be dose-sparing and cost-saving. This pilot randomized study assessed Cervarix (R) and Gardasil (R) administered either intramuscularly or intradermally, in different doses (full-dose or reduced to 20%) by different methods (needle and syringe or PharmaJet needle-free jet injection device). Following an initial reactogenicity study of 10 male subjects, sexually naive women aged 18-26 years were randomized to the eight study groups to receive vaccine at 0, 2 and 6 months. 42 female subjects were enrolled and complete data were available for 40 subjects. Intradermal administration of either vaccine raised no safety concerns but was more reactogenic than intramuscular administration, although still tolerable. All subjects demonstrated a sero-conversion (titre >= 1:320) by Day 95. Further evaluation of intradermal HPV vaccination and its potential for cost reduction in resource poor settings is warranted. (C) 2013 Elsevier Ltd. All rights reserved.
All Author(s) ListNelson EAS, Lam HS, Choi KC, Ho WCS, Fung LWE, Cheng FWT, Sung RYT, Royals M, Chan PKS
Journal nameVaccine
Year2013
Month7
Day25
Volume Number31
Issue Number34
PublisherElsevier
Pages3452 - 3460
ISSN0264-410X
eISSN1873-2518
LanguagesEnglish-United Kingdom
KeywordsHuman papillomavirus; Intradermal; Vaccine
Web of Science Subject CategoriesImmunology; IMMUNOLOGY; Medicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Research & Experimental Medicine

Last updated on 2020-29-10 at 00:17