A novel miR-193a-5p-YY1-APC regulatory axis in human endometrioid endometrial adenocarcinoma
Publication in refereed journal


Times Cited
Web of Science43WOS source URL (as at 04/06/2020) Click here for the latest count
Altmetrics Information
.

Other information
AbstractAberrant expression and altered function of transcription factors (TFs) have vital roles in many aspects of tumor development and progression. In this study, we investigated the functional significance of a TF, Yin Yang1 (YY1) in tumorigenesis of endometrioid endometrial carcinoma (EEC). We demonstrated that YY1 is upregulated in EEC cell lines and primary tumors; and its expression is associated with tumor stages. Depletion of YY1 inhibits EEC cell proliferation and migration both in vitro and in vivo, whereas overexpression of YY1 promotes EEC cell growth. These results suggest that YY1 functions as an oncogenic factor in EEC. Transcriptome analysis revealed a significant effect of YY1 on critical aspects of EEC tumorigenesis through inhibition of APC expression. Further mechanistic investigation uncovered a new epigenetic silencing mode of APC by YY1 through recruitment of EZH2 and trimethylation of histone 3 lysine 27 on its promoter region. Moreover, YY1 overexpression was found to be a consequence of miR-193a-5p downregulation through direct miR-193a-5p-YY1 interplay. Our results therefore establish a novel miR-193a-5p-YY1-APC axis, which contributes to EEC development, and may serve as future intervention target.
All Author(s) ListYang Y, Zhou L, Lu L, Wang L, Li X, Jiang P, Chan LKY, Zhang T, Yu J, Kwong J, Cheung T, Chung T, Mak K, Sun H, Wang H
Journal nameOncogene
Detailed descriptionTo ORKTS: Duplicate record P125310 and P120348 deleted.
Year2013
Month7
Day18
Volume Number32
Issue Number29
PublisherNature Publishing Group: Open Access Hybrid Model Option B
Pages3432 - 3442
ISSN0950-9232
eISSN1476-5594
LanguagesEnglish-United Kingdom
KeywordsAPC; EEC; EZH2; H3K27me3; microRNA; YY1
Web of Science Subject CategoriesBiochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Cell Biology; CELL BIOLOGY; Genetics & Heredity; GENETICS & HEREDITY; Oncology; ONCOLOGY

Last updated on 2020-04-06 at 23:29