Minimal change disease caused by exposure to mercury-containing skin lightening cream: a report of 4 cases
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AbstractMercury is a known cause of nephrotic syndrome and the underlying renal pathology in most of the reported cases was membranous nephropathy. We describe here 4 cases of minimal change disease following exposure to mercury-containing skin lightening cream for 2 - 6 months. The mercury content of the facial creams was very high (7,420 - 30,000 parts per million). All patients were female and presented with nephrotic syndrome and heavy proteinuria (8.35 - 20.69 g/d). The blood and urine mercury levels were 26 - 129 nmol/l and 316 - 2,521 nmol/d, respectively. Renal biopsy revealed minimal change disease (MCD) in all patients. The use of cosmetic cream was stopped and chelation therapy with D-penicillamine was given. Two patients were also given steroids. The time for blood mercury level to normalize was 1 - 7 months, whereas it took longer for urine mercury level to normalize (9 - 16 months). All patients had complete remission of proteinuria and the time to normalization of proteinuria was 1 - 9 months. Mercury-containing skin lightening cream is hazardous because skin absorption of mercury can cause minimal change disease. The public should be warned of the danger of using such products. In patients presenting with nephrotic syndrome, a detailed history should be taken, including the use of skin lightening cream. With regard to renal pathology, apart from membranous nephropathy, minimal change disease should be included as another pathological entity caused by mercury exposure or intoxication.
All Author(s) ListTang HL, Mak YF, Chu KH, Lee W, Fung SKS, Chan TYK, Tong KL
Journal nameClinical Nephrology
Year2013
Month4
Day1
Volume Number79
Issue Number4
PublisherDUSTRI-VERLAG DR KARL FEISTLE
Pages326 - 329
ISSN0301-0430
LanguagesEnglish-United Kingdom
Keywordscosmetics; glomerulonephritis; mercury; minimal change disease; nephrotic syndrome
Web of Science Subject CategoriesUrology & Nephrology; UROLOGY & NEPHROLOGY

Last updated on 2020-13-07 at 01:09