Dysregulation and crosstalk of cellular signaling pathways in colon carcinogenesis
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AbstractMultiple intracellular signaling pathways, such as Wnt/beta-catenin signaling, epidermal growth factor receptor/Ras signaling, and p53 signaling are frequently dysregulated in colorectal cancer. Recent evidence also points to the involvement of signaling pathways in the developmental process, including Notch signaling, Hedgehog signaling, and Hippo signaling. Dysregulation of these signaling pathways contribute to the acquisition of malignant phenotypes, including unchecked cell cycle progression, evasion of apoptosis, induction of genetic instability, and enhanced invasiveness and metastasis. Understanding their relative importance and crosstalk will provide a rational basis for anticancer drug development. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
All Author(s) ListWu WKK, Wang XJ, Cheng ASL, Luo MXM, Ng SSM, To KF, Chan FKL, Cho CH, Sung JJY, Yu J
Journal nameCritical Reviews in Oncology/Hematology
Detailed descriptionTo ORKTS: Duplicate records P131114 & P126447 deleted.
Volume Number86
Issue Number3
Pages251 - 277
LanguagesEnglish-United Kingdom
KeywordsCell signaling; Colorectal cancer; p53; Ras; Wnt
Web of Science Subject CategoriesHematology; HEMATOLOGY; Oncology; ONCOLOGY

Last updated on 2020-17-10 at 01:30