Long-term vitamin A deficiency induces alteration of adult mouse spermatogenesis and spermatogonial differentiation: direct effect on spermatogonial gene expression and indirect effects via somatic cells
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AbstractThe objective of this study was to further understand the genetic mechanisms of vitamin A deficiency (VAD) induced arrest of spermatogonial stem-cell differentiation. Vitamin A and its derivatives (the retinoids) participate in many physiological processes including vision, cellular differentiation and reproduction. VAD affects spermatogenesis, the subject of our present study. Spermatogenesis is a highly regulated process of differentiation and complex morphologic alterations that leads to the formation of sperm in the seminiferous epithelium. VAD causes early cessation of spermatogenesis, characterized by degeneration of meiotic germ cells, leading to seminiferous tubules containing mostly type A spermatogonia and Sertoli cells. These observations led us to the hypothesis that VAD affects not only germ cells but also somatic cells.
All Author(s) ListBoucheron-Houston C, Canterel-Thouennon L, Lee TL, Baxendale V, Nagrani S, Chan WY, Rennert OM
Journal nameJournal of Nutritional Biochemistry
Detailed descriptionTo ORKTS: doi: 10.1016/j.jnutbio.2012.08.013
Volume Number24
Issue Number6
Pages1123 - 1135
LanguagesEnglish-United Kingdom
KeywordsGene expression; Spermatogenesis; Vitamin A deficiency
Web of Science Subject CategoriesBiochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Nutrition & Dietetics; NUTRITION & DIETETICS

Last updated on 2020-02-08 at 01:25