The citrus flavonone hesperetin prevents letrozole-induced bone loss in a mouse model of breast cancer
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摘要Aromatase is a key enzyme in estrogen synthesis, and aromatase inhibitors (AIs) have been developed for treating estrogen-responsive breast cancer. Because of its nondiscriminatory inhibition of estrogen synthesis, patients treated with AIs also contract diseases typically associated with estrogen deficiency, such as bone deterioration. Our laboratory found that the citrus flavonone hesperetin could inhibit aromatase, and the selective estrogen receptor modulator nature of flavonoid might counteract the undesirable effect of AIs. In the present study, we employed an established postmenopausal model for breast carcinogenesis to examine the drug interaction between hesperetin and letrozole, one of the AIs. Athymic mice were ovariectomized and transplanted with aromatase-overexpressing MCF-7 cells (MCF-7aro). Hesperetin was administered in the diet at 5000 ppm, and letrozole was injected scat different doses. Results showed that either hesperetin or letrozole could reduce plasma estrogen level and inhibit tumor growth. Most importantly, the letrozole-induced bone loss measured as bone volume fraction was reversed by hesperetin without compromising on the deterrence of MCF-7aro tumor growth. Taken together, the present study suggested that hesperetin could be a potential cotherapeutic agent to AI. (C) 2013 Elsevier Inc. All rights reserved.
著者Li FJ, Chow S, Cheung WH, Chan FL, Chen SA, Leung LK
期刊名稱Journal of Nutritional Biochemistry
出版年份2013
月份6
日期1
卷號24
期次6
出版社Elsevier
頁次1112 - 1116
國際標準期刊號0955-2863
電子國際標準期刊號1873-4847
語言英式英語
關鍵詞Aromatase; Breast cancer cells; Hesperetin; Letrozole
Web of Science 學科類別Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Nutrition & Dietetics; NUTRITION & DIETETICS

上次更新時間 2020-20-09 於 01:34