Alterations of bone geometry, density, microarchitecture, and biomechanical properties in systemic lupus erythematosus on long-term glucocorticoid: a case-control study using HR-pQCT
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AbstractCompared to controls, HR-pQCT at distal radius of SLE patients on chronic glucocorticoid (SLE/GC) revealed reduced bone area, vBMD, deteriorated microarchitecture, and unevenly distributed stresses limited to cortical bone. Despite similar trabecular quality, whole bone strength decreased in patients. These alterations may partly explain high fracture rates in SLE/GC.
All Author(s) ListTang XL, Qin L, Kwok AW, Zhu TY, Kun EW, Hung VW, Griffith JF, Leung PC, Li EK, Tam LS
Journal nameOsteoporosis International
Volume Number24
Issue Number6
PublisherSpringer Verlag (Germany)
Pages1817 - 1826
LanguagesEnglish-United Kingdom
KeywordsBiomechanical properties; Bone microarchitecture; Bone mineral density; FE analysis; HR-pQCT; Systemic lupus erythematosus
Web of Science Subject CategoriesEndocrinology & Metabolism; ENDOCRINOLOGY & METABOLISM

Last updated on 2021-14-04 at 23:41