Folate-conjugated Fe3O4@SiO2@gold nanorods@mesoporous SiO2 hybrid nanomaterial: a theranostic agent for magnetic resonance imaging and photothermal therapy
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AbstractIn this paper, we investigated the functional imaging and targeted therapeutic properties of core@multi-shell nanoparticles composed of a superparamagnetic iron oxide (SPIO) core and gold nanorods (GNRs) in the mesoporous silica shells functionalized with folic acid (Fe3O4@SiO2@GNRs@mSiO(2)-FA). The as-synthesized five-component hybrid nanocomposite was revealed to have insignificant cytotoxicity. Intracellular uptake of the nanoparticles was studied in the folate receptor over-expressing human epidermoid carcinoma of the nasopharynx (KB) cells. Due to their magnetic/optical properties as well as the folate targeting potential, compared with Fe3O4@SiO2@GNRs@mSiO(2) nanoparticles, higher cellular uptake efficiency was observed for Fe3O4@SiO2@GNRs@mSiO(2)-FA nanoparticles in KB cells. Characterizations were achieved using both dark field and magnetic resonance (MR) imaging techniques. The hyperthermia induced by Fe3O4@SiO2@GNRs@mSiO(2)-FA nanoparticles resulted in a higher cytotoxicity in KB cells. Thus, the Fe3O4@SiO2@GNRs@mSiO(2)-FA hybrid nanomaterial is an effective and promising MR imaging and photothermal therapy agent for folate-receptor over-expressing cancer cells.
All Author(s) ListWang DW, Zhu XM, Lee SF, Chan HM, Li HW, Kong SK, Yu JC, Cheng CHK, Wang YXJ, Leung KCF
Journal nameJournal of Materials Chemistry B
Detailed descriptionTo ORKTS: doi: 10.1039/C3TB20090F
Volume Number1
Issue Number23
PublisherRoyal Society of Chemistry
Pages2934 - 2942
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesMaterials Science; Materials Science, Biomaterials

Last updated on 2021-06-05 at 01:32