Treatment of nonalcoholic steatohepatitis with probiotics. A proof-of-concept study
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摘要Background. Probiotics have profound effect on nonalcoholic steatohepatitis (NASH) in animal models. We aimed to test the hypothesis that probiotics treatment was superior to usual care in reducing liver fat in NASH patients. Material and methods. Patients with histology-proven NASH were randomized to receive probiotics (n = 10) or usual care (n = 10) for 6 months. The Lepicol probiotic formula contained Lactobacillus plantarum, Lactobacillus deslbrueckii, Lactobacillus acidophilus, Lactobacillus rhamnosus and Bifidobacterium bifidum. The primary endpoint was change in intrahepatic triglyceride content (IHTG), as measured by proton-magnetic resonance spectroscopy, from baseline to month 6. Secondary endpoints included changes in liver biochemistry and metabolic profile. Results. IHTG decreased from 22.6 +/- 8.2% to 14.9 +/- 7.0% in the probiotic group (P = 0.034) but remained static in the usual care group (16.9 +/- 6.1% to 16.0 +/- 6.6%; P = 0.55). Six subjects in the probiotic group had IHTG reduced by more than 30% from baseline, compared to 2 subjects in the usual care group (P = 0.17). The probiotic group also had greater reduction in serum aspartate aminotransferase level (P = 0.008). On the other hand, the use of probiotics was not associated with changes in body mass index, waist circumference, glucose and lipid levels. Conclusions. Probiotics treatment may reduce liver fat and AST level in NASH patients. The therapeutic potential of probiotics in NASH should be tested in larger studies.
著者Wong VWS, Wong GLH, Chim AML, Chu WCW, Yeung DKW, Li KCT, Chan HLY
期刊名稱ANNALS OF HEPATOLOGY
出版年份2013
月份3
日期1
卷號12
期次2
出版社MEXICAN ASSOC HEPATOLOGY
頁次256 - 262
國際標準期刊號1665-2681
語言英式英語
關鍵詞Fatty liver; Obesity; Prebiotics; Randomized controlled trial
Web of Science 學科類別Gastroenterology & Hepatology; GASTROENTEROLOGY & HEPATOLOGY

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