Zeranol upregulates corticotropin releasing hormone expression in the placental cell line JEG-3
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香港中文大學研究人員

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摘要Corticotrophin-releasing hormone (CRH) plays a pivotal role in the control of parturition in human. Increased amount of plasma CRH is associated with pre-mature delivery. Zeranol or alpha-zearalanol is a mycotoxin produced by fungi in the Fusarium family. Unlike other mycotoxins, exposure to zeranol appears to have minimal health risk. In North America, it is used as a growth-promoting agent in livestock. Because of the health concern of zeranol residue in meat, this practice has not been adopted in Europe. In our study zeranol could induce CRH protein expression in JEG-3 cells as low as 0.1 nM. As electrophoretic mobility shift assay indicated an increase in the CRE binding activity in CRH promoter, the induction was likely triggered by transcriptional regulation. We further looked into the signal transduction pathway and PKC delta and ERK-1/2 were found to be activated. This study showed that zeranol could increase CRH expression in placental cells, and the findings might be a concern for pregnant women. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
著者Wang YF, Tan WJ, Leung LK
期刊名稱Toxicology Letters
出版年份2013
月份6
日期7
卷號219
期次3
出版社Elsevier
頁次218 - 222
國際標準期刊號0378-4274
電子國際標準期刊號1879-3169
語言英式英語
關鍵詞CRH; Placental cells; Zeranol
Web of Science 學科類別Toxicology; TOXICOLOGY

上次更新時間 2020-22-05 於 00:49