Comparisons of oseltamivir-resistant (H275Y) and concurrent oseltamivir-susceptible seasonal influenza A(H1N1) virus infections in hospitalized adults, 2008-2009
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摘要In an observational cohort study, we found that adults hospitalized for oseltamivir-resistant (H275Y) seasonal H1N1 influenza (n=46) were older than those infected with oseltamivir-susceptible strains (n=31) [74(IQR 5983) versus 64(IQR 4876) years; P=0 center dot 045], and most had major comorbidities (78% versus 65%). Disease severity and clinical outcomes were comparable between the two groups: radiographic pneumonia 4042%, supplemental oxygen use 4748%, critical illness 1113%, median duration of hospitalization 56days, death rate 69%. Failure to receive effective antiviral therapy was associated with progression to critical illness (23% versus 0%, P=0 center dot 016) and death (20% versus 0%, P=0 center dot 033) in hospitalized patients with seasonal H1N1 influenza.
著者Chan MCW, Lee N, Lui GCY, Ngai KKL, Wong RYK, Choi KW, Chan PKS
期刊名稱Influenza and Other Respiratory Viruses
詳細描述volume 7; issue 3\n\nTo ORKTS: Lee N as corresponding author
出版年份2013
月份5
日期1
卷號7
期次3
出版社Wiley Open Access
頁次235 - 239
國際標準期刊號1750-2640
電子國際標準期刊號1750-2659
語言英式英語
關鍵詞H275Y; oseltamivir; seasonal influenza A(H1N1) virus
Web of Science 學科類別Infectious Diseases; INFECTIOUS DISEASES; Virology; VIROLOGY

上次更新時間 2020-27-11 於 01:20