Comparisons of oseltamivir-resistant (H275Y) and concurrent oseltamivir-susceptible seasonal influenza A(H1N1) virus infections in hospitalized adults, 2008-2009
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AbstractIn an observational cohort study, we found that adults hospitalized for oseltamivir-resistant (H275Y) seasonal H1N1 influenza (n=46) were older than those infected with oseltamivir-susceptible strains (n=31) [74(IQR 5983) versus 64(IQR 4876) years; P=0 center dot 045], and most had major comorbidities (78% versus 65%). Disease severity and clinical outcomes were comparable between the two groups: radiographic pneumonia 4042%, supplemental oxygen use 4748%, critical illness 1113%, median duration of hospitalization 56days, death rate 69%. Failure to receive effective antiviral therapy was associated with progression to critical illness (23% versus 0%, P=0 center dot 016) and death (20% versus 0%, P=0 center dot 033) in hospitalized patients with seasonal H1N1 influenza.
All Author(s) ListChan MCW, Lee N, Lui GCY, Ngai KKL, Wong RYK, Choi KW, Chan PKS
Journal nameInfluenza and Other Respiratory Viruses
Detailed descriptionvolume 7; issue 3\n\nTo ORKTS: Lee N as corresponding author
Volume Number7
Issue Number3
PublisherWiley Open Access
Pages235 - 239
LanguagesEnglish-United Kingdom
KeywordsH275Y; oseltamivir; seasonal influenza A(H1N1) virus
Web of Science Subject CategoriesInfectious Diseases; INFECTIOUS DISEASES; Virology; VIROLOGY

Last updated on 2020-17-10 at 01:19