Full-length Mst1 exhibits growth promoting function in human hepatocellular carcinoma cells
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AbstractThe putative tumor suppressor Mst1, when cleaved to its 36 kDa cleaved form, amplifies apoptotic signals. We found that Mst1 was predominantly expressed in its full-length form in 76% (17/25 cases) of hepatocellular carcinoma (HCC) tumors. Mst1 cleavage was basically absent in HCC cells. Ectopic full-length Mst1 expression increased the growth of HCC cells by 55-80% within 3 days after transfection. Expression of exogenous NORE1B, a tumor suppressor commonly lost in HCC tumors (similar to 56% of our cohort), was sufficient to suppress the growth promotion of full-length Mst1. Hence, Mst1 exhibits a growth promoting activity in HCC cells upon NORE1B downregulation. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
All Author(s) ListNg YK, Lau WS, Lui VWY, Cheng ASL, Ng PKS, Tsui SKW, Cheung YS, Lai PBS
Journal nameFEBS Letters
Detailed descriptionTo ORKTS:

Year2013
Month3
Day1
Volume Number587
Issue Number5
PublisherWiley: 12 months
Pages496 - 503
ISSN0014-5793
eISSN1873-3468
LanguagesEnglish-United Kingdom
KeywordsAkt; Hep3B; Huh7; NORE1B; PLC/PRF/5; Staurosporine; Stk4
Web of Science Subject CategoriesBiochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Biophysics; BIOPHYSICS; Cell Biology; CELL BIOLOGY

Last updated on 2020-25-05 at 00:02