Ca2+ mobilization in cumulus cells: Role in oocyte maturation and acrosome reaction
Publication in refereed journal

香港中文大學研究人員

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摘要The cumulus mass is a group of cells surrounding the oocyte. Cumulus cells are known to play a role in a number of reproductive events including oocyte maturation and acrosome reaction. Calcium mobilization in cumulus cells has been implicated-in the process of oocyte maturation and acrosome reaction; however, its exact role remains elusive. In this review, we summarize the findings on Ca2+ mobilization in cumulus cells, with particular focus on (1) the gonadotropin/paracrine factors-induced cumulus Ca2+ mobilization and its downstream signaling pathways in oocyte maturation and (2) the sperm-derived factors-induced cumulus Ca2+ mobilization in the cross-talk between cumulus and sperm and thus acrosome reaction. The evidence suggests that as an important signaling event, Ca2+ mobilization in cumulus cells is important to germ cell development and function, and thus essential to fertilization and reproduction. (C) 2012 Elsevier Ltd. All rights reserved.
著者Chen H, Kui C, Chan HC
期刊名稱Cell Calcium
詳細描述To ORKTS: doi: 10.1016/j.ceca.2012.11.007; Confirmed with Mr. Y.W. Chung (Prof. Chan's Technician) that Mr. Christopher Kui is a visitor of Prof. Chan
出版年份2013
月份1
日期1
卷號53
期次1
出版社Elsevier
頁次68 - 75
國際標準期刊號0143-4160
語言英式英語
關鍵詞Acrosome reaction; Ca2+ mobilization; Cumulus cells; Oocyte maturation
Web of Science 學科類別Cell Biology; CELL BIOLOGY

上次更新時間 2020-25-05 於 00:02