Ca2+ mobilization in cumulus cells: Role in oocyte maturation and acrosome reaction
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AbstractThe cumulus mass is a group of cells surrounding the oocyte. Cumulus cells are known to play a role in a number of reproductive events including oocyte maturation and acrosome reaction. Calcium mobilization in cumulus cells has been implicated-in the process of oocyte maturation and acrosome reaction; however, its exact role remains elusive. In this review, we summarize the findings on Ca2+ mobilization in cumulus cells, with particular focus on (1) the gonadotropin/paracrine factors-induced cumulus Ca2+ mobilization and its downstream signaling pathways in oocyte maturation and (2) the sperm-derived factors-induced cumulus Ca2+ mobilization in the cross-talk between cumulus and sperm and thus acrosome reaction. The evidence suggests that as an important signaling event, Ca2+ mobilization in cumulus cells is important to germ cell development and function, and thus essential to fertilization and reproduction. (C) 2012 Elsevier Ltd. All rights reserved.
All Author(s) ListChen H, Kui C, Chan HC
Journal nameCell Calcium
Detailed descriptionTo ORKTS: doi: 10.1016/j.ceca.2012.11.007; Confirmed with Mr. Y.W. Chung (Prof. Chan's Technician) that Mr. Christopher Kui is a visitor of Prof. Chan
Year2013
Month1
Day1
Volume Number53
Issue Number1
PublisherElsevier
Pages68 - 75
ISSN0143-4160
LanguagesEnglish-United Kingdom
KeywordsAcrosome reaction; Ca2+ mobilization; Cumulus cells; Oocyte maturation
Web of Science Subject CategoriesCell Biology; CELL BIOLOGY

Last updated on 2020-28-03 at 00:24