A herbal formula containing roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) inhibits inflammatory mediators in LPS-stimulated RAW 264.7 macrophages through inhibition of nuclear factor kappa B (NF kappa B) pathway
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AbstractEthnopharmacological relevance: The herbal formula DG, containing roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen), has long history in treating cardiovascular diseases. It has been shown to be able to reduce intima-media thickening in coronary patients in our previous clinical study. Since intima-media thickening is the hallmark of atherosclerotic disease, the etiology of which is inflammation of the arterial wall, the mechanism underlying the effect of DG may be related to its anti-inflammatory activities.
All Author(s) ListCheung DWS, Koon CM, Wat E, Ko CH, Chan JYW, Yew DTW, Leung PC, Chan WY, Lau CBS, Fung KP
Journal nameJournal of Ethnopharmacology
Volume Number145
Issue Number3
Pages776 - 783
LanguagesEnglish-United Kingdom
KeywordsAnti-inflammation; Danshen; Gegen; NF kappa B; Pueraria lobata; Salvia miltiorrhiza
Web of Science Subject CategoriesChemistry, Medicinal; CHEMISTRY, MEDICINAL; Integrative & Complementary Medicine; INTEGRATIVE & COMPLEMENTARY MEDICINE; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Plant Sciences; PLANT SCIENCES

Last updated on 2021-24-09 at 00:07