Ovarian Cancer Stem Cells: A New Target for Cancer Therapy
Publication in refereed journal


摘要Ovarian cancer is a highly lethal disease among all gynecologic malignancies and is the fifth leading cause of cancer-related death in women. Although the standard combination of surgery and chemotherapy was initially effective in patients with ovarian cancer, disease relapse commonly occurred due to the generation of chemoresistance. It has been reported that cancer stem cells (CSCs) are involved in drug resistance and cancer recurrence. Over the past decades, increasing studies have been done to identify CSCs from human ovarian cancer cells. The present paper will summarize different investigations on ovarian CSCs, including isolation, mechanisms of chemoresistance, and therapeutic approaches. Although there are still numerous challenges to translate basic research to clinical applications, understanding the molecular details of CSCs is essential for developing effective strategies to prevent ovarian cancer and its recurrence.
著者Zhan QL, Wang CM, Ngai S
期刊名稱BioMed Research International
詳細描述PMID:23509802 [PubMed - in process] Free PMC Article
出版社Hindawi Publishing Corporation
Web of Science 學科類別Biotechnology & Applied Microbiology; Medicine, Research & Experimental; Research & Experimental Medicine

上次更新時間 2020-20-11 於 00:50