Ovarian Cancer Stem Cells: A New Target for Cancer Therapy
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AbstractOvarian cancer is a highly lethal disease among all gynecologic malignancies and is the fifth leading cause of cancer-related death in women. Although the standard combination of surgery and chemotherapy was initially effective in patients with ovarian cancer, disease relapse commonly occurred due to the generation of chemoresistance. It has been reported that cancer stem cells (CSCs) are involved in drug resistance and cancer recurrence. Over the past decades, increasing studies have been done to identify CSCs from human ovarian cancer cells. The present paper will summarize different investigations on ovarian CSCs, including isolation, mechanisms of chemoresistance, and therapeutic approaches. Although there are still numerous challenges to translate basic research to clinical applications, understanding the molecular details of CSCs is essential for developing effective strategies to prevent ovarian cancer and its recurrence.
All Author(s) ListZhan QL, Wang CM, Ngai S
Journal nameBioMed Research International
Detailed descriptionPMID:23509802 [PubMed - in process] Free PMC Article
PublisherHindawi Publishing Corporation
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesBiotechnology & Applied Microbiology; Medicine, Research & Experimental; Research & Experimental Medicine

Last updated on 2021-15-09 at 00:34