Double restriction-enzyme digestion improves the coverage and accuracy of genome-wide CpG methylation profiling by reduced representation bisulfite sequencing
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AbstractBackground: Reduced representation bisulfite sequencing (RRBS) was developed to measure DNA methylation of high-CG regions at single base-pair resolution, and has been widely used because of its minimal DNA requirements and cost efficacy; however, the CpG coverage of genomic regions is restricted and important regions with low-CG will be ignored in DNA methylation profiling. This method could be improved to generate a more comprehensive representation.
All Author(s) ListWang JW, Xia YD, Li LL, Gong DS, Yao Y, Luo HJ, Lu HL, Yi N, Wu HL, Zhang XQ, Tao Q, Gao F
Journal nameBMC Genomics
Year2013
Month1
Day16
Volume Number14
PublisherBIOMED CENTRAL LTD
ISSN1471-2164
LanguagesEnglish-United Kingdom
KeywordsCpG coverage; DNA methylation; Double-enzyme RRBS; Single-enzyme RRBS
Web of Science Subject CategoriesBiotechnology & Applied Microbiology; BIOTECHNOLOGY & APPLIED MICROBIOLOGY; Genetics & Heredity; GENETICS & HEREDITY

Last updated on 2020-20-11 at 00:49