Involvements of calcium channel and potassium channel in Danshen and Gegen decoction induced vasodilation in porcine coronary LAD artery
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摘要Danshen (Salviae Miltiorrhizae Radix) and Gegen (Puerariae Lobatae Radix) have been widely used in treating cardiovascular diseases for thousands of years in China. The present study was carried out to evaluate the effects of a Danshen and Gegen decoction (DG) on the vascular reactivity of a porcine isolated coronary artery and the underlying mechanisms involved. Porcine coronary rings were precontracted with 15 nM U46619. The involvement of endothelium-dependent mechanisms was explored by removing the endothelium; the involvement of potassium channels was investigated by the pretreatment of the artery rings with various blockers, and the involvement of the calcium channels was investigated by incubating the artery rings with Ca2+-free buffer and priming them with high [K+] prior to adding CaCl2 to elicit contraction. The involvement of Ca2+ sensitization was explored by evaluating the Rho-activity expression.
著者Hu F, Koon CM, Chan JYW, Lau KM, Kwan YW, Fung KP
期刊名稱Phytomedicine
出版年份2012
月份9
日期15
卷號19
期次12
出版社Elsevier
頁次1051 - 1058
國際標準期刊號0944-7113
電子國際標準期刊號1618-095X
語言英式英語
關鍵詞Calcium; Danshen and Gegen decoction (DG); Endothelium; Myosin light chain; Potassium; Vasodilation
Web of Science 學科類別Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Integrative & Complementary Medicine; INTEGRATIVE & COMPLEMENTARY MEDICINE; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Plant Sciences; PLANT SCIENCES

上次更新時間 2020-20-09 於 01:27