Antagonist-mediated down-regulation of toll-like receptors increases the prevalence of human papillomavirus infection in systemic lupus erythematosus
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AbstractIntroduction: Prevalence of an abnormal Papanicolaou smear was significantly increased in lupus patients in cross-sectional studies, associated with a higher prevalence of high-risk human papillomavirus (HPV) infection. The nucleic acid-specific Toll-like receptors (TLRs) locate at the endolysosomal compartments and trigger the induction of cytokines for the innate immune response. This study evaluated whether abnormal host innate immune response in lupus patients may enhance HPV persistence.
All Author(s) ListYu SL, Chan PKS, Wong CK, Szeto CC, Ho SC, So K, Yu MY, Yim SF, Cheung TH, Wong MCS, Cheung JLK, Yeung ACM, Li EK, Tam LS
Journal nameArthritis Research and Therapy
Detailed description2012.
Volume Number14
Issue Number2
PublisherBioMed Central
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesRheumatology; RHEUMATOLOGY

Last updated on 2021-11-05 at 00:07