Genetic polymorphisms of molecules involved in host immune response to dengue virus infection
Publication in refereed journal

香港中文大學研究人員

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摘要The dengue virus (DENV) belongs to the flavivirus family. Each of the four distinct serotypes of this virus is capable of causing human disease, especially in tropical and subtropical areas. The majority of people infected with DENV manifest asymptomatic or dengue fever with flu-like self-limited symptoms. However, a small portion of patients emerge with severe manifestations referred to as dengue hemorrhagic fever, which has a high mortality rate if not treated promptly. The host immune system, which plays important roles throughout the whole process of DENV infection, has been confirmed to have double-edged effects on DENV infection. Recently, much attention has been paid to the genetic heterogeneity of molecules involved in the host immune response to DENV infection. This heterogeneity has been proved to be the determining factor for DENV disease orientation. The present review discusses the primary functions and single nucleotide polymorphisms of some critical molecules in the human DENV immunological defense, especially the polymorphism locus associated with the DENV pathogenesis and disease susceptibility.
著者Fang X, Hu Z, Shang WL, Zhu JM, Xu CS, Rao XC
期刊名稱FEMS Immunology and Medical Microbiology
出版年份2012
月份11
日期1
卷號66
期次2
出版社Oxford University Press (OUP): Policy B - Oxford Open Option D
頁次134 - 146
國際標準期刊號0928-8244
語言英式英語
關鍵詞dengue virus; genetics; human immune; molecules; pathogenesis; polymorphisms
Web of Science 學科類別Immunology; IMMUNOLOGY; Infectious Diseases; INFECTIOUS DISEASES; Microbiology; MICROBIOLOGY

上次更新時間 2021-11-05 於 00:17