Relationship of Intrarenal Gene Expression and the Histological Class of Lupus Nephritis — A Study on Repeat Renal Biopsy
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AbstractObjective. To study the role of tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK)/Fn14 and the interferon-inducible protein (IP-10)/CXCR3 axis in lupus nephritis (LN).

Methods. We studied 113 patients with LN who had had repeat renal biopsies. Glomerular and tubulointerstitial messenger RNA expression of TWEAK, Fn14, IP-10, and CXCR3 were quantified.

Results. Glomerular Fn14 expression decreased when changed from proliferative or mixed nephritis to membranous nephropathy (p = 0.016), and increased when changed from membranous to proliferative or mixed nephritis (p = 0.0006). On the other hand, tubulointerstitial TWEAK expression decreased when changed from proliferative or mixed nephritis to membranous nephropathy (p = 0.004), and increased when changed from membranous nephropathy to proliferative nephritis (p = 0.010). Tubulointerstitial IP-10 expression decreased when changed from proliferative or mixed nephritis to membranous nephropathy (p < 0.0001). Histological activity index correlated significantly with the glomerular expression of Fn14 (r = 0.421, p < 0.0001) and tubulointerstitial expression of TWEAK (r = 0.413, p < 0.0001) and IP-10 (r = 0.472, p < 0.0001).

Conclusion. Glomerular Fn14 and tubulointerstitial TWEAK and IP-10 expression appeared to have consistent changes in relation to the histological class of LN and correlated with the histological activity index. Our findings suggest a specific role of these genes in the pathogenesis of LN.
All Author(s) ListJianxin Lu, Cheuk-Chun Szeto, Lai-Shan Tam, Fernand Mac-Moune Lai, Edmund Kwok-Ming Li, Kai-Ming Chow, Philip Kam-Tao Li, Bonnie Ching-Ha Kwan
Journal nameJournal of Rheumatology
Year2012
Month10
Day1
Volume Number39
Issue Number10
PublisherJournal of Rheumatology
Pages1942 - 1947
ISSN0315-162X
eISSN1499-2752
LanguagesEnglish-United Kingdom
KeywordsSYSTEMIC LUPUS ERYTHEMATOSUS, GLOMERULONEPHRITIS
Web of Science Subject CategoriesRheumatology; RHEUMATOLOGY

Last updated on 2020-06-07 at 00:03