Mechanism of cadmium-induced cytotoxicity on the ZFL zebrafish liver cell line
Publication in refereed journal

香港中文大學研究人員

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其它資訊
摘要The cadmium ion (Cd2+) is a highly toxic metal ion; however, its hepatic toxic effects are not very well characterized in a systematic manner. In this study, a zebrafish liver cell line, ZFL was used as a model to investigate the mechanism of Cd2+-induced cytotoxicity on hepatocytes. The intracellular level of reactive oxygen species decreased following the administration of Cd2+; antioxidant levels and related enzyme activities and gene expression were detected, showing that the toxic effects of Cd2+ might not be coupled to oxidative stress. To understand the cytotoxic effects of Cd2+ on ZFL cells after Cd-2+ exposure, a total of 77 differentially expressed proteins were detected by two-dimensional gel electrophoresis; 43 of them were further identified by MALDI-TOF-MS. The proteins that responded to Cd2+ in ZFL cells were related to stress response, transporters, regulation of transcription, redox homeostasis, or different signaling pathways, with half of these proteins having metal ion binding capabilities.
著者Zhu JY, Chan KM
期刊名稱Metallomics
出版年份2012
月份10
日期1
卷號4
期次10
出版社Royal Society of Chemistry
頁次1064 - 1076
國際標準期刊號1756-5901
電子國際標準期刊號1756-591X
語言英式英語
Web of Science 學科類別Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY

上次更新時間 2020-27-10 於 00:14