Mechanism of cadmium-induced cytotoxicity on the ZFL zebrafish liver cell line
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AbstractThe cadmium ion (Cd2+) is a highly toxic metal ion; however, its hepatic toxic effects are not very well characterized in a systematic manner. In this study, a zebrafish liver cell line, ZFL was used as a model to investigate the mechanism of Cd2+-induced cytotoxicity on hepatocytes. The intracellular level of reactive oxygen species decreased following the administration of Cd2+; antioxidant levels and related enzyme activities and gene expression were detected, showing that the toxic effects of Cd2+ might not be coupled to oxidative stress. To understand the cytotoxic effects of Cd2+ on ZFL cells after Cd-2+ exposure, a total of 77 differentially expressed proteins were detected by two-dimensional gel electrophoresis; 43 of them were further identified by MALDI-TOF-MS. The proteins that responded to Cd2+ in ZFL cells were related to stress response, transporters, regulation of transcription, redox homeostasis, or different signaling pathways, with half of these proteins having metal ion binding capabilities.
All Author(s) ListZhu JY, Chan KM
Journal nameMetallomics
Volume Number4
Issue Number10
PublisherRoyal Society of Chemistry
Pages1064 - 1076
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesBiochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY

Last updated on 2020-29-07 at 01:26