The MAP30 protein from bitter gourd (Momordica charantia) seeds promotes apoptosis in liver cancer cells in vitro and in vivo
Publication in refereed journal


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摘要Human hepatocellular carcinoma Hop G2 cells and Hep G2-bearing mice were used as in vitro and in vivo models to assess the efficacy and safety of MAP30, a natural component from Momordica charantia, as an anticancer agent against liver cancer. Molecular studies disclosed the contribution of both caspase-8 regulated extrinsic and caspase-9 regulated intrinsic caspase cascades in MAP30-induced cell apoptosis. The antitumor potential was also effective in Hep G2-bearing nude mice. Since bitter gourd is a staple in many Asian countries, MAP30 would serve as a novel and relatively safe agent for prophylaxis and treatment of liver cancer. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
著者Fang EF, Zhang CZY, Wong JH, Shen JY, Li CH, Ng TB
期刊名稱Cancer Letters
詳細描述To ORKTS: doi: 10.1016/j.canlet.2012.05.005
出版年份2012
月份11
日期1
卷號324
期次1
出版社Elsevier
頁次66 - 74
國際標準期刊號0304-3835
電子國際標準期刊號1872-7980
語言英式英語
關鍵詞Apoptosis; Bitter gourd; Hepatocellular carcinoma; MAP30; Momordica charantia
Web of Science 學科類別Oncology; ONCOLOGY

上次更新時間 2021-17-09 於 01:23