The MAP30 protein from bitter gourd (Momordica charantia) seeds promotes apoptosis in liver cancer cells in vitro and in vivo
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AbstractHuman hepatocellular carcinoma Hop G2 cells and Hep G2-bearing mice were used as in vitro and in vivo models to assess the efficacy and safety of MAP30, a natural component from Momordica charantia, as an anticancer agent against liver cancer. Molecular studies disclosed the contribution of both caspase-8 regulated extrinsic and caspase-9 regulated intrinsic caspase cascades in MAP30-induced cell apoptosis. The antitumor potential was also effective in Hep G2-bearing nude mice. Since bitter gourd is a staple in many Asian countries, MAP30 would serve as a novel and relatively safe agent for prophylaxis and treatment of liver cancer. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
All Author(s) ListFang EF, Zhang CZY, Wong JH, Shen JY, Li CH, Ng TB
Journal nameCancer Letters
Detailed descriptionTo ORKTS: doi: 10.1016/j.canlet.2012.05.005
Volume Number324
Issue Number1
Pages66 - 74
LanguagesEnglish-United Kingdom
KeywordsApoptosis; Bitter gourd; Hepatocellular carcinoma; MAP30; Momordica charantia
Web of Science Subject CategoriesOncology; ONCOLOGY

Last updated on 2020-17-11 at 23:43