Accessing the genomic effects of naked nanoceria in murine neuronal cells
Publication in refereed journal


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摘要Cerium oxide nanoparticles (nanoceria) are engineered nanoparticles whose versatility is due to their unique redox properties. We and others have demonstrated that naked nanoceria can act as antioxidants to protect cells against oxidative damage. Although the redox properties may be beneficial, the genome-wide effects of nanoceria on gene transcription and associated biological processes remain elusive. Here we applied a functional genomic approach to examine the genome-wide effects of nanoceria on global gene transcription and cellular functions in mouse neuronal cells. Importantly, we demonstrated that nanoceria induced chemical- and size-specific changes in the murine neuronal cell transcriptome. The nanoceria contributed more than 83% of the population of uniquely altered genes and were associated with a unique spectrum of genes related to neurological disease, cell cycle control, and growth. These observations suggest that an in-depth assessment of potential health effects of naked nanoceria and other naked nanoparticles is both necessary and imminent.
著者Lee TL, Raitano JM, Rennert OM, Chan SW, Chan WY
期刊名稱Nanomedicine: Nanotechnology, Biology and Medicine
詳細描述To ORKTS: doi: 10.1016/j.nano.2011.08.005
出版年份2012
月份7
日期1
卷號8
期次5
出版社Elsevier
頁次599 - 608
國際標準期刊號1549-9634
電子國際標準期刊號1549-9642
語言英式英語
關鍵詞Cerium oxide; Genomics; Nanoceria; Nanoparticles; Neuronal cells
Web of Science 學科類別Medicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Nanoscience & Nanotechnology; NANOSCIENCE & NANOTECHNOLOGY; Research & Experimental Medicine; Science & Technology - Other Topics

上次更新時間 2020-17-11 於 23:37