Accessing the genomic effects of naked nanoceria in murine neuronal cells
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AbstractCerium oxide nanoparticles (nanoceria) are engineered nanoparticles whose versatility is due to their unique redox properties. We and others have demonstrated that naked nanoceria can act as antioxidants to protect cells against oxidative damage. Although the redox properties may be beneficial, the genome-wide effects of nanoceria on gene transcription and associated biological processes remain elusive. Here we applied a functional genomic approach to examine the genome-wide effects of nanoceria on global gene transcription and cellular functions in mouse neuronal cells. Importantly, we demonstrated that nanoceria induced chemical- and size-specific changes in the murine neuronal cell transcriptome. The nanoceria contributed more than 83% of the population of uniquely altered genes and were associated with a unique spectrum of genes related to neurological disease, cell cycle control, and growth. These observations suggest that an in-depth assessment of potential health effects of naked nanoceria and other naked nanoparticles is both necessary and imminent.
All Author(s) ListLee TL, Raitano JM, Rennert OM, Chan SW, Chan WY
Journal nameNanomedicine: Nanotechnology, Biology and Medicine
Detailed descriptionTo ORKTS: doi: 10.1016/j.nano.2011.08.005
Year2012
Month7
Day1
Volume Number8
Issue Number5
PublisherElsevier
Pages599 - 608
ISSN1549-9634
eISSN1549-9642
LanguagesEnglish-United Kingdom
KeywordsCerium oxide; Genomics; Nanoceria; Nanoparticles; Neuronal cells
Web of Science Subject CategoriesMedicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Nanoscience & Nanotechnology; NANOSCIENCE & NANOTECHNOLOGY; Research & Experimental Medicine; Science & Technology - Other Topics

Last updated on 2020-28-10 at 00:47