Salidroside Protects Human Erythrocytes against Hydrogen Peroxide-Induced Apoptosis
Publication in refereed journal

香港中文大學研究人員

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摘要Rhodiola rosea is a commonly used folk medicine for the treatment of high altitude sickness, mountain malhypoxia, and anoxia. Its active ingredient, salidroside [2-(4-hydroxyphenyl)ethyl beta-D-glucopyranoside (1)], has been reported to have a broad spectrum of biological effects. However, the protective role of 1 in human erythrocytes remains unclear. This study therefore has investigated the effects of 1 on oxidative stress-induced apoptosis in human erythrocytes (also known as eryptosis or erythroptosis). Compound 1 increased cell survival significantly and prevented human erythrocytes from undergoing eryptosis/erythroptosis mediated by H2O2, as confirmed by the decreased expression of phosphatidylserine On the cell surface and reduced leakage of calcein through the damaged membrane. Mechanistically, 1 was found to exert its protective effects through its antioxidative activity and the inhibition of caspase-3 activation and stress-induced intracellular Ca2+ rise in a dose-dependent manner. Compound 1 is a protective agent in human erythrocytes against oxidative stress and may be a good adaptogen to enhance the body's resistance to stress and fatigue.
著者Qian EW, Ge DT, Kong SK
期刊名稱Journal of Natural Products
出版年份2012
月份4
日期1
卷號75
期次4
出版社American Chemical Society
頁次531 - 537
國際標準期刊號0163-3864
電子國際標準期刊號1520-6025
語言英式英語
Web of Science 學科類別Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Plant Sciences; PLANT SCIENCES

上次更新時間 2020-23-10 於 01:15