Effects of DL-3-n-Butylphthalide on Vascular Dementia and Angiogenesis
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Abstract3-n-Butylphthalide (NBP) is a compound extracted from Chinese celery and is used as an anti-hypertensive herbal medicine for treating stroke patients. The aim of this study is to demonstrate the effects and mechanisms of this compound through in vitro and in vivo experiments. Culture experiments were performed by adding hydrogen peroxide (H2O2) to SH-SY5Y cells. From the MTT assay result, enhanced cell survival was observed with DL-NBP treatment, regardless of whether they are added before, simultaneously with or after the addition of H2O2. For the in vivo experiment, Spontaneously Hypertensive rats and Wistar Kyoto control rats with chronic cerebral ischemia, which were induced by bilateral transection of the common carotid arteries, were given DL-NBP. Their performances in the place navigation test and spatial probe test in the Morris Water Maze have significantly improved compared with the DL-NBP untreated animals, indicating an improvement in spatial learning and memory in the ischemic-animals. In addition, in the chick embryonic chorioallantoic membrane assay, angiogenesis was more vigorous under the effects of DL-NBP, together with increased expression of growth factors, VEGF, VEGF-receptor and bFGF. All these suggested that one of the mechanisms of DL-NBP might be ameliorating vascular dementia and promoting angiogenesis.
All Author(s) ListZhang LH, Lu LH, Chan WM, Huang Y, Wai MSM, Yew DT
Journal nameNeurochemical Research
Detailed descriptionTo ORKTS: doi: 10.1007/s11064-011-0663-3
Year2012
Month5
Day1
Volume Number37
Issue Number5
PublisherSPRINGER/PLENUM PUBLISHERS
Pages911 - 919
ISSN0364-3190
LanguagesEnglish-United Kingdom
KeywordsAngiogenesis; Culture; DL-3-n-Butylphthalide (NBP); Morris water maze; Rats; Vascular dementia
Web of Science Subject CategoriesBiochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Neurosciences; NEUROSCIENCES; Neurosciences & Neurology

Last updated on 2020-24-11 at 00:29