Effect of Body Mass Index on Serum Prostate-specific Antigen Levels among Patients Presenting with Lower Urinary Tract Symptoms
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摘要Purpose: Studies among asymptomatic male subjects have suggested that a higher body mass index (BMI) is associated with lower serum prostate-specific antigen (PSA) levels. We aimed to investigate whether a similar effect also occurs in patients presenting with lower urinary tract symptoms (LUTS) to a urological unit and its potential implications. Methods: A retrospective review was carried out at our centre between 2005 and 2009. The serum PSA and BMI of the patients were retrieved from a prospectively collected database. The BMI was divided into normal (<23kg/m(2)), overweight (23-27kg/m(2)), and obese (>27kg/m(2)) categories according to WHO recommendation for analysis of the association with PSA level. Results: A total of 1,612 patients with a mean age of 64.6 were included. The mean PSA levels for the normal, overweight, and obese patients were 4.84, 4.54, and 3.95 ng/ml, respectively, with a significant negative correlation (Spearman's coefficient= -0.05, p=0.03). A significant negative association between PSA and BMI among the normal, overweight, and obese groups was also demonstrated by analysis of variance (p=0.01). After adjusting for age differences, there was a significant difference between PSA level for obese patients with a BMI>27 (3.95ng/ml) and non-obese patients with a BMI<27 (4.67ng/ml) with analysis of covariance (p=0.02). Conclusion: In symptomatic male patients, a higher BMI was significantly associated with lower PSA levels. BMI should be considered in the interpretation of serum PSA levels in overweight and obese patients presenting with LUTS.
著者Chiu PKF, Wong AYF, Hou SM, Yip SKH, Ng CF
期刊名稱Asian Pacific Journal of Cancer Prevention
出版年份2011
月份1
日期1
卷號12
期次8
出版社Asian Pacific Education Press Ltd.
頁次1937 - 1940
國際標準期刊號1513-7368
語言英式英語
關鍵詞Body mass index; lower urinary tract symptoms; obesity; prostate cancer; PSA
Web of Science 學科類別Oncology; ONCOLOGY

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