Genetically-manipulated adult stem cells as therapeutic agents and gene delivery vehicle for wound repair and regeneration
Publication in refereed journal

香港中文大學研究人員

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摘要Wound therapy remains a clinical challenge and much effort has been focused on the development of novel therapeutic approaches for wound management. New knowledge about the way in which signals control wound cellular and molecular behavior has promoted the topical application of multipotent stem cells and bioactive molecules to injured tissue, for skin regeneration with less scar formation. However, limited clinical success indicates that the effective delivery of polypeptides and therapeutic cells, with controlled releasing profile, is a major challenge which is yet to be overcome. Recently, a technique in which the genetically-manipulated stem cells were used both as the therapeutic agents and the vehicle for gene delivery for wound treatment - a method which serves to provide regenerative cells and bioactive genes within an optimal environment of regulatory molecular expression for wound sites - has emerged as a promising strategy for wound regenerative therapy.
著者Peng LH, Tsang SY, Tabata Y, Gao JQ
期刊名稱Journal of Controlled Release
出版年份2012
月份2
日期10
卷號157
期次3
出版社ELSEVIER SCIENCE BV
頁次321 - 330
國際標準期刊號0168-3659
電子國際標準期刊號1873-4995
語言英式英語
關鍵詞Adult stem cells; Gene delivery; Regeneration; Wound repair
Web of Science 學科類別Chemistry; Chemistry, Multidisciplinary; CHEMISTRY, MULTIDISCIPLINARY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

上次更新時間 2021-11-05 於 00:15