Effective antitumor immunity against murine gliomas using dendritic cells transduced with hTERTC27 recombinant adenovirus
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AbstracthTERTC27, a 27-kDa hTERT C-terminal polypeptide has been demonstrated to cause hTERT-positive He La cell apoptosis and inhibits the growth of mouse melanoma. hTERTC27 has been associated with telomere dysfunction, regulation of gene-regulated apoptosis, the cell cycle and activation of natural killer (NK) cells, but its mechanism of action is not fully understood. Here, we report that dendritic cells (DCs) transduced with hTERTC27 can increase T-cell proliferation, and augment the concentration of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) in the supernatants of T cells. It can also induce antigen-specific cytotoxic T lymphocytes (CTL) against glioma cells in vitro. Moreover, hTERTC27 gene-transduced DCs exhibit a very potent cytotoxicity to glioma cells in vivo. It could prolong the survival time and inhibit the growth of glioma-bearing mice. These data suggest that hTERTC27 gene-transduced DCs can efficiently enhance immunity against gliomas in vitro and in vivo.
All Author(s) ListGong HX, He L, Li XP, Wang YD, Li Y, Huang JJ, Wang ZL, Xie D, Kung HF, Peng Y
Journal nameOncology Reports
Volume Number27
Issue Number4
PublisherSpandidos Publications
Pages1163 - 1169
LanguagesEnglish-United Kingdom
Keywordscytotoxic T lymphocytes; dendritic cells; hTERTC27; immunotherapy
Web of Science Subject CategoriesOncology; ONCOLOGY

Last updated on 2020-07-08 at 00:48