Androgen rather than estrogen up-regulates brain-type cytochrome P450 aromatase (cyp19a1b) gene via tissue-specific promoters in the hermaphrodite teleost ricefield eel Monopterus albus
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摘要CYP19A1 in the brain and pituitary of vertebrates is important for reproductive and non-reproductive processes. In teleosts, it is broadly accepted that estradiol (E-2) up-regulates cyp19a1b gene via a positive autoregulatory loop. Our present study, however, showed that E-2 did not up-regulate ricefield eel cyp19a1b in the hypothalamus and pituitary, whereas dihydrotestosterone (DHT) or testosterone (T) stimulated cyp19a1b expression only in the pituitary. Two tissue-specific promoters, namely promoter I and II directing the expression in the brain and pituitary respectively, were identified. Promoter I contained a non-consensus estrogen response element (ERE), and consequently did not respond to E-2. Promoter II contained an androgen response element (ARE) and consequently responded to DHT. Taken together, these results demonstrated a novel steroidal regulation of cyp19a1b gene expression and an alternative usage of tissue-specific cyp19a1b promoters in the brain and pituitary of a teleost species, the ricefield eel. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
著者Zhang Y, Zhang S, Zhou WL, Ye X, Ge W, Cheng CHK, Lin HR, Zhang WM, Zhang LH
期刊名稱Molecular and Cellular Endocrinology
出版年份2012
月份3
日期5
卷號350
期次1
出版社ELSEVIER IRELAND LTD
頁次125 - 135
國際標準期刊號0303-7207
語言英式英語
關鍵詞Androgen; cyp19a1b; Estrogen; Monopterus albus; Tissue-specific promoter
Web of Science 學科類別Cell Biology; CELL BIOLOGY; Endocrinology & Metabolism; ENDOCRINOLOGY & METABOLISM

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