Blueberry extract prolongs lifespan of Drosophila melanogaster
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摘要Blueberry possesses greater antioxidant capacity than most other fruits and vegetables. The present study investigated the lifespan-prolonging activity of blueberry extracts in fruit flies and explored its underlying mechanism. Results revealed that blueberry extracts at 5 mg/ml in diet could significantly extend the mean lifespan of fruit flies by 10%, accompanied by up-regulating gene expression of superoxide dismutase (SOD), catalase (CAT) and Rpn11 and down-regulating Methuselah (MTH) gene. Intensive H2O2 and Paraquat challenge tests showed that lifespan was only extended in Oregon-R wild type flies but not in SODn108 or Cat(n1) mutant strains. Chronic Paraquat exposure shortened the maximum survival time from 73 to 35 days and decreased the climbing ability by 60% while blueberry extracts at 5 mg/ml in diet could significantly increase the survival rate and partially restore the climbing ability with up-regulating SOD, CAT, and Rpn11. Furthermore, gustatory assay demonstrated that those changes were not due to the variation of food intake between the control and the experimental diet containing 5 mg/ml blueberry extracts. It was therefore concluded that the lifespan-prolonging activity of blueberry extracts was at least partially associated with its interactions with MTH. Rpn11, and endogenous antioxidant enzymes SOD and CAT. (C) 2011 Elsevier Inc. All rights reserved.
著者Peng C, Zuo YY, Kwan KM, Liang YT, Ma KY, Chan HYE, Huang Y, Yu HJ, Chen ZY
期刊名稱Experimental Gerontology
出版年份2012
月份2
日期1
卷號47
期次2
出版社Elsevier
頁次170 - 178
國際標準期刊號0531-5565
電子國際標準期刊號1873-6815
語言英式英語
關鍵詞Blueberry; Catalase; Fruit fly; Lifespan; Superoxide dismutase
Web of Science 學科類別Geriatrics & Gerontology; GERIATRICS & GERONTOLOGY

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