Prevalence of Survivor Bias in Observational Studies on Fresh Frozen Plasma:Erythrocyte Ratios in Trauma Requiring Massive Transfusion
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AbstractObservational studies on transfusion in trauma comparing high versus low plasma: erythrocyte ratio were prone to survivor bias because plasma administration typically started later than erythrocytes. Therefore, early deaths were categorized in the low plasma: erythrocyte group, whereas early survivors had a higher chance of receiving a higher ratio. When early deaths were excluded, however, a bias against higher ratio can be created. Survivor bias could be reduced by performing before-and-after studies or treating the plasma: erythrocyte ratio as a time-dependent covariate.
All Author(s) ListHo AMH, Dion PW, Yeung JHH, Holcomb JB, Critchley LAH, Ng CSH, Karmakar MK, Cheung CW, Rainer TH
Journal nameAnesthesiology
Volume Number116
Issue Number3
PublisherLippincott, Williams & Wilkins: No Hybrid Open Access
Pages716 - 728
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesAnesthesiology; ANESTHESIOLOGY

Last updated on 2021-16-09 at 00:49