Prevalence of Survivor Bias in Observational Studies on Fresh Frozen Plasma:Erythrocyte Ratios in Trauma Requiring Massive Transfusion
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AbstractObservational studies on transfusion in trauma comparing high versus low plasma: erythrocyte ratio were prone to survivor bias because plasma administration typically started later than erythrocytes. Therefore, early deaths were categorized in the low plasma: erythrocyte group, whereas early survivors had a higher chance of receiving a higher ratio. When early deaths were excluded, however, a bias against higher ratio can be created. Survivor bias could be reduced by performing before-and-after studies or treating the plasma: erythrocyte ratio as a time-dependent covariate.
All Author(s) ListHo AMH, Dion PW, Yeung JHH, Holcomb JB, Critchley LAH, Ng CSH, Karmakar MK, Cheung CW, Rainer TH
Journal nameAnesthesiology
Year2012
Month3
Day1
Volume Number116
Issue Number3
PublisherLippincott, Williams & Wilkins: No Hybrid Open Access
Pages716 - 728
ISSN0003-3022
eISSN1528-1175
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesAnesthesiology; ANESTHESIOLOGY

Last updated on 2020-27-09 at 00:49