The miR-124 regulates the expression of BACE1/beta-secretase correlated with cell death in Alzheimer's disease
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AbstractThe role of miR-124 on the expression of beta-site APP cleaving enzyme 1 (BACE1), an important cleavager of amyloid precursor protein that plays a pivotal role in the p-amyloid production, was studied in this paper using cellular models for Alzheimer' disease (AD) of cultured PC12 cell lines and primary cultured hippocampal neurons. The aim of the present study was to uncover novel potential miR-124 targets and shed light on its function in the cellular AD model. MiR-124 expression was steadily altered when its mimic and inhibitor were transfected in vitro. The results showed the expression of BACE1, one of the potential functional downstream targets of miR-124, was well correlated with cell death induced by A beta neurotoxicity, and its expression level could be up- and down-regulated by suppression or over expression of miR-124 level respectively. These findings suggest that miR-124 may work as a basilic regulating factor to alleviate cell death in the process of AD by targeting BACE1, play an essential role in the control of BACE1 gene expression, and might be considered as a novel therapeutic target in treating (C) 2011 Elsevier Ireland Ltd. All rights reserved.
All Author(s) ListFang MR, Wang J, Zhang XB, Geng Y, Hu ZY, Rudd JA, Ling SC, Chen W, Han S
Journal nameToxicology Letters
Detailed descriptionTo ORKTS: doi: 10.1016/j.toxlet.2011.11.032
Volume Number209
Issue Number1
Pages94 - 105
LanguagesEnglish-United Kingdom
KeywordsA beta-induced neurotoxicity; Alzheimer's disease; BACE1/beta-secretase; Cell death; miR-124
Web of Science Subject CategoriesToxicology; TOXICOLOGY

Last updated on 2020-27-11 at 00:52