Promoter characterization and genomic organization of the human X11 beta gene APBA2
Publication in refereed journal


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摘要Overexpression of neuronal adaptor protein X11 beta has been shown to decrease the production of amyloid-beta, a toxic peptide deposited in Alzheimer's disease brains. Therefore, manipulation of the X11 beta level may represent a potential therapeutic strategy for Alzheimer's disease. As X11 beta expression can be regulated at the transcription level, we determined the genomic organization and the promoter of the human X11 beta gene, amyloid beta A4 precursor protein-binding family A member 2 (APBA2). By RNA ligase-mediated rapid amplification of cDNA ends, a single APBA2 transcription start site and the complete sequence of exon 1 were identified. The APBA2 promoter was located upstream of exon 1 and was more active in neurons. The core promoter contains several CpG dinucleotides, and was strongly suppressed by DNA methylation. In addition, mutagenesis analysis revealed a putative Pax5-binding site within the promoter. Together, APBA2 contains a potent neuronal promoter whose activity may be regulated by DNA methylation and Pax5. NeuroReport 23: 146-151 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
著者Hao Y, Chai KH, McLoughlin DM, Chan HYE, Lau KF
期刊名稱NeuroReport
出版年份2012
月份2
日期15
卷號23
期次3
出版社LIPPINCOTT WILLIAMS & WILKINS
頁次146 - 151
國際標準期刊號0959-4965
電子國際標準期刊號1473-558X
語言英式英語
關鍵詞Alzheimer's disease; APBA2; promoter; X11 beta
Web of Science 學科類別Neurosciences; NEUROSCIENCES; Neurosciences & Neurology

上次更新時間 2021-19-01 於 00:29