Blue light-activated hypocrellin B damages ovarian cancer cells
Publication in refereed journal


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摘要In the present study, a novel blue light source from LED was used to activate hypocrellin B in ovarian cancer HO-8910 cells. Hypporellin B concentration was kept at 2.5 mu M and light doses from 0.5-4.0 J/cm(2). Photocytotoxicity was investigated using MTT reduction assay and light microscopy after light irradiation. Cellular morphology was observed using transmission electron microscopy (TEM). MTT assay showed that the cytotoxicity of blue light-activated hypocrellin B in HO-8910 cells increased along with light dose. The observations from light microscopy reinforced the above results. TEM showed that microvillin disappearance, vacuole formation, chromatin condensation, and topical apoptotic body were observed in the cells treated by both light and hypocrellin B. The findings demonstrated that blue light from LED source could effectively activate hypocrellin B to cause the destruction of HO-8910 cells, indicating that Blue light-activated hypocrellin B might be potential therapeutic strategy in the management of ovarian cancer.
著者Jiang Y, Leung AWN, Xiang JY, Xu CS
期刊名稱Laser Physics
出版年份2012
月份1
日期1
卷號22
期次1
出版社MAIK NAUKA/INTERPERIODICA/SPRINGER
頁次300 - 305
國際標準期刊號1054-660X
語言英式英語
Web of Science 學科類別Optics; OPTICS; Physics; Physics, Applied; PHYSICS, APPLIED

上次更新時間 2021-23-02 於 00:32