Preferential base pairing modes of T.T mismatches
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AbstractIt has long been recognized that T.T mismatches can adopt two different modes of exchangeable wobble base pairs in which no preferential pairing mode has been observed. In this study, we have performed a systematic nuclear magnetic resonance (NMR) investigation to study the sequence context effect on the pairing modes of T.T mismatches. Our results reveal for the first time that preferential pairing mode does exist in T.T mismatches with specific type of flanking base pairs. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
All Author(s) ListHe GY, Kwok CK, Lam SL
Journal nameFEBS Letters
Year2011
Month12
Day15
Volume Number585
Issue Number24
PublisherWiley: 12 months
Pages3953 - 3958
ISSN0014-5793
eISSN1873-3468
LanguagesEnglish-United Kingdom
KeywordsBase pairing mode; DNA; NMR; T.T mismatch
Web of Science Subject CategoriesBiochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Biophysics; BIOPHYSICS; Cell Biology; CELL BIOLOGY

Last updated on 2021-15-09 at 00:05