PCR-cloning of tilapia ATP7A cDNA and its mRNA levels in tissues of tilapia following copper administrations
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AbstractWe are studying the toxicity of copper to tilapia and zebrafish and have found that the copper tolerance of tilapia and the sensitivity of zebrafish were due to several proteins' regulation mechanisms that were related to the effects of reactive oxygen species, mitochondrion copper transport, and stress response. To further reveal the mechanism of copper tolerance and sensitivity in tilapia and zebrafish, a full length cDNA of ATP7A was obtained in tilapia. Using real time quantitative PCR, the differential regulations of ATP7A in tilapia and zebrafish were studied. It was found that Cu(2+) gave a higher induction of ATP7A in tilapia than zebrafish, both in vivo and in vitro. These results suggest that the copper tolerance of tilapia may be due to higher expression level of ATP7A. (C) 2011 Elsevier B.V. All rights reserved.
All Author(s) ListChen DS, Chan KM
Journal nameAquatic Toxicology
Volume Number105
Issue Number3-4
Pages717 - 727
LanguagesEnglish-United Kingdom
KeywordsCopper tolerance; Copper transporters; Copper uptake
Web of Science Subject CategoriesMarine & Freshwater Biology; MARINE & FRESHWATER BIOLOGY; Toxicology; TOXICOLOGY

Last updated on 2020-05-08 at 02:39