AluScan: a method for genome-wide scanning of sequence and structure variations in the human genome
Publication in refereed journal


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摘要Background: To complement next-generation sequencing technologies, there is a pressing need for efficient pre-sequencing capture methods with reduced costs and DNA requirement. The Alu family of short interspersed nucleotide elements is the most abundant type of transposable elements in the human genome and a recognized source of genome instability. With over one million Alu elements distributed throughout the genome, they are well positioned to facilitate genome-wide sequence amplification and capture of regions likely to harbor genetic variation hotspots of biological relevance.
著者Mei LL, Ding XF, Tsang SY, Pun FW, Ng SK, Yang JF, Zhao CY, Li DZ, Wan WQ, Yu CH, Tan TC, Poon WS, Leung GKK, Ng HK, Zhang LW, Xue H
期刊名稱BMC Genomics
出版年份2011
月份11
日期17
卷號12
出版社BIOMED CENTRAL LTD
國際標準期刊號1471-2164
語言英式英語
Web of Science 學科類別Biotechnology & Applied Microbiology; BIOTECHNOLOGY & APPLIED MICROBIOLOGY; Genetics & Heredity; GENETICS & HEREDITY

上次更新時間 2020-27-10 於 00:44