AluScan: a method for genome-wide scanning of sequence and structure variations in the human genome
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AbstractBackground: To complement next-generation sequencing technologies, there is a pressing need for efficient pre-sequencing capture methods with reduced costs and DNA requirement. The Alu family of short interspersed nucleotide elements is the most abundant type of transposable elements in the human genome and a recognized source of genome instability. With over one million Alu elements distributed throughout the genome, they are well positioned to facilitate genome-wide sequence amplification and capture of regions likely to harbor genetic variation hotspots of biological relevance.
All Author(s) ListMei LL, Ding XF, Tsang SY, Pun FW, Ng SK, Yang JF, Zhao CY, Li DZ, Wan WQ, Yu CH, Tan TC, Poon WS, Leung GKK, Ng HK, Zhang LW, Xue H
Journal nameBMC Genomics
Volume Number12
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesBiotechnology & Applied Microbiology; BIOTECHNOLOGY & APPLIED MICROBIOLOGY; Genetics & Heredity; GENETICS & HEREDITY

Last updated on 2021-12-10 at 00:16