Genetically manipulated adult stem cells for wound healing
Publication in refereed journal


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摘要New knowledge of the signal controls and activities of adult stem cells (ASCs) involved in wound repair have led to extensive investigation of the topical delivery of biomacromolecules and multipotent stem cells to injured tissues for scar-less regeneration. The transplantation of genetically recombinant stem cells, which have roles as both therapeutics and carriers for gene delivery to wound sites, represents an attractive strategy for wound treatment. Here, we compare viral and non-viral vectors and three-dimensional scaffold-based transfection strategies in terms of their biosafety, recombinant efficiency and influence on the differentiation of ASCs, to indicate the future direction of the application of recombinant ASCs in wound treatment.
著者Peng LH, Fung KP, Leung PC, Gao JQ
期刊名稱Drug Discovery Today
詳細描述To ORKTS: doi:10.1016/j.drudis.2011.07.009.
出版年份2011
月份11
日期1
卷號16
期次21-22
出版社ELSEVIER SCI LTD
頁次957 - 966
國際標準期刊號1359-6446
語言英式英語
Web of Science 學科類別Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

上次更新時間 2021-02-05 於 23:52