Heme oxygenase-1 system and gastrointestinal inflammation: A short review
Publication in refereed journal


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摘要Heme oxygenase-1 (HO-1) system catalyzes heme to biologically active products: carbon monoxide, biliverdin/bilirubin and free iron. It is involved in maintaining cellular homeostasis and many physiological and pathophysiological processes. A growing body of evidence indicates that HO-1 activation may play an important protective role in acute and chronic inflammation of gastrointestinal tract. This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal inflammation studied to date. The ability to upregulate HO-1 by pharmacological means or using gene therapy may offer therapeutic strategies for gastrointestinal inflammation in the future. (C) 2011 Baishideng. All rights reserved.
著者Zhu X, Fan WG, Li DP, Kung HF, Lin MCM
期刊名稱World Journal of Gastroenterology
出版年份2011
月份10
日期14
卷號17
期次38
出版社W J G PRESS
頁次4283 - 4288
國際標準期刊號1007-9327
電子國際標準期刊號2219-2840
語言英式英語
關鍵詞Gastrointestinal inflammation; Heme oxygenase-1
Web of Science 學科類別Gastroenterology & Hepatology; GASTROENTEROLOGY & HEPATOLOGY

上次更新時間 2020-24-10 於 01:40